Lipidic metabolism in parasitic platyhelminthes

This review is an account of research into the biochemistry of lipids of platyhelminth parasites. Taking as high benchmark major metabolic pathways of vertebrates we summarize catabolic and synthesis routes now thought to be characteristic of this group. We emphasize the litlle recent information that exists on intermediary metabolism in these parasites. However, new data may be challenging old paradigms that have rule lipid metabolic studies for decades. Of particular relevance is the finding that fatty acid oxidation is possible under certain conditions, and metabolites related to sterols synthesis have been identified. Recent work on lipids turnover and remodeling of host taken phospholipids is also reviewed. Relevant contributions concerning eicosanoid metabolism are included in this chapter. The review concludes with a brief look at some lipid binding proteins related to the acquisition and transport of lipids from the host and distribution inside the cell. Correspondence/Reprint request: Dr. Adriana Esteves, Biochemistry Section, Department of Cellular and Molecular Biology, Faculty of Sciences, UdelaR, Iguá 4225, Montevideo, Uruguay E-mail:[email protected] Gabriela Alvite & Adriana Esteves 2